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. 2016 Apr 24;23(5):519–530. doi: 10.1111/acem.12938

Table 5.

Frequency of Other Adverse Events Reported in Included Reviews

Reviews Emesis Without Aspiration Pain with Injection Paradoxical Reactions Unpleasant Recovery Reactionsa
Ketamine
Deasy 20109 310/2,525 (12.3%)
13 studies 		— — 213/2,102 (14.8%)
8 studies
Green 200910 694/8,353 (8.3%)
32 studies 		— — 630/8282 (7.6%)
32 studies
Howes 200415 159/2,251 (7.1%)
8 studies 		— — 93/1,720 (5.4%)
6 studies
Mace 200417 192/2,148 (8.9%)
10 studies 		— 7/1,180 (0.8%)
1 study 		230/1,499 (15.3%)
5 studies
Migita 200612 12/130 (9.2%)
1 study 		— — 7/130 (5.4%)
1 study
Mistry 200514 176/1,584 (11.1%)
8 studies 		— — 268/1,755 (15.3%)
7 studies
NICE 201020 428/3,624 (11.8%)
11 studies 		— — 183/1,178 (15.5%)
3 studies
Midazolam
Jameson 20117 — — — —
Leroy 201019 5/2,424 (0.2%)
2 studies 		— — 9/1244 (0.7%)
1 study
Mace 200417 4/1,180 (0.3%)
1 study 		— — —
NICE 201020 45/1,748 (2.6%)
5 studies 		— — —
Nitrous Oxide
Leroy 201019 59/982 (6.0%)
2 studies 		— — —
Migita 200612 — — — —
NICE 201020 30/709 (4.2%)
2 studies 		— — —
Pedersen 201316 127/5,779 (2.2%)
1 study 		— — —
Faddy 200513 1 study — — —
Propofol
Lamond 20108 24/17,066b (0.1%)
60 studies 		951/17,066b (5.6%)
60 studies 		— —
Leroy 201019 49c
1 study 		— — —
Mace 200417 — — — —
Migita 200612 — 3/43 (7.0%)
1 study 		— —
NICE 201020 49/49,836 (0.1%)
1 study 		— — —
Symington 200618 1/393 (0.3%)
1 study 		7/194 (3.6%)
4 studies 		— —

Data are reported as n/N (%) and number of studies reported.

a

These were measured variably across studies and include: dysphoria (or dysphoric reactions), agitation (any, mild, moderate, severe), emergence reaction.

b

Denominator represents all sedations analyzed in the review, not just those that occurred in the ED.

c

Outcomes reported per 10,000 patients.