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. 2016 Oct;57:10–20. doi: 10.1016/j.bbi.2016.04.003

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© 2016 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 4 — Intestinal microbiota changes correlate with gut noradrenaline (NE) levels (A) Mice that had undergone 60 min MCAo and 72 h reperfusion show significantly increased NE levels in gut tissue homogenates (ANOVA: F_2,12 = 10.02, p = 0.003; Posthoc TukeyHSD significance <0.001, with the labels a and b denoting samples significantly different, error bars are standard error of the mean, n = 5. (B) Peptococcaceae relative abundance correlate with intestinal NE levels (Regression: R² = 0.370, F_1,13 = 7.56, p = 0.02), Equation of line y = 0.322 * x + 0.114. (C) Prevotellaceae decrease in the intestinal proportionally to increasing NE levels after injury (Regression: R² = 0.512, F_1,13 = 13.58, p = 0.003), Equation of line y = −3.299 * x + 3.480. Samples are as follows: ○ = Naïve; △ = Sham 72 h post treatment; □ = Brain injury 72 h post treatment.