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. Author manuscript; available in PMC: 2017 Sep 1.
Published in final edited form as: Diabetes Obes Metab. 2016 Sep;18(Suppl 1):78–86. doi: 10.1111/dom.12729

Figure 1. β-cell metabolism under normal conditions.

Figure 1

Glucose metabolism is the key determinant of ATP generation and the triggering of insulin secretion, whereas fatty acids modulate insulin secretion via Gly/FFA cycling. Arrow thickness indicates rate of metabolism. Abbreviations: FFA, free fatty acid; Gly/FFA, glycerolipid-free fatty acid cycle; ACC, acetyl-coA carboxylase; FAS, fatty acid synthase; GK, glucokinase; PDH, pyruvate dehydrogenase; PC, pyruvate carboxylase.