Figure 1.

Cases where there was consensus agreement of ADEM diagnosis when reviewing neuroimaging. A 5-year-old male patient (Case 1b26023) with a 5-day history of pyrexia, increasing lethargy, and mild cough/cold; on presentation he had left-sided weakness, ptosis, and unequal pupils noted. (a–c) Axial T2 and (d–f) FLAIR images demonstrating hyperintensity within medial thalamus (arrows; a, d), left cerebral peduncle (arrow; b, c) and left dentate nucleus (not shown) extending in to cerebellar pontine angle (arrow; c, f); with some more widespread white matter lesions as seen on axial flair images in centrum semiovale (g). (h–i) A 5-year-old female patient (Case 1b26029) with a history of lethargy, leg weakness, and unsteadiness walking; also had recent episodes of urinary incontinence. (h) Axial T2 imaging demonstrating bilateral basal ganglia and thalamic lesions and (i) widespread deep and subcortical white matter lesions.