Fig. 1.

Normal life span of synuclein null mutant mice. Kaplan–Meier survival plot demonstrates survival rate up to the age of 2 years in cohorts of wild-type mice and mice carrying homozygous synuclein null alleles in any of 7 possible combinations. Log rank and generalized Wilcoxon tests for equality of survival did not reveal significant difference between any of studied animal groups (p > 0.05). The number of animals in groups: 35 (α⁺β⁺γ⁺), 23 (α⁻β⁺γ⁺), 21 (α⁺β⁻γ⁺), 33 (α⁺β⁺γ⁻), 29 (α⁻β⁺γ⁻), 39 (α⁺β⁻γ⁻), 34 (α⁻β⁻γ⁺), and 28 (α⁻β⁻γ⁻).