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. 2016 Aug 3;49(4):1394–1406. doi: 10.3892/ijo.2016.3646

Figure 5.

Figure 5

SPARC regulates VEGF-A expression through miR-410. The VEGF-A expression levels in NB1691 and SK-N-BE(2) in cell culture supernatants were measured by ELISA. SPARC overexpression reduced levels of VEGF-A in both cell lines. (A) Addition of miR-410 inhibitor reversed the effect of miR-410 in NB1691 cell line (SPARC vs. SPARC + miR-410 inhibitor *P<0.05, control vs. SPARC *P<0.05, **P<0.001). Angiogenesis in neuroblastoma is primarily mediated by VEGF-A. (B) The present study shows that overexpression of SPARC induces expression of miR-410, which specifically inhibits VEGF-A thereby inhibiting angiogenesis.