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. 2016 Sep 13;11(9):e0162875. doi: 10.1371/journal.pone.0162875

Fig 2. Effects of YHS in D2KO mice assessed in the tail flick and formalin paw licking assays.

Fig 2

(A) Effects of YHS (200 mg/kg) in D2KO mice assessed in the tail flick assay (n = 10). Tail-flick latencies were measured 120 min following drug administration. One-way ANOVA indicated a significant drug effect (F3,36 = 12.53, P < 0.0001) followed by Bonferroni post hoc test: YHS vs vehicle, *** P < 0.001, N.S., not significant; KO vs WT, ## P < 0.01. (B) Effects of YHS (200 mg/kg) in D2KO mice assessed in the formalin paw licking assay (n = 6). One-way ANOVA indicated significant drug effects in both Phase I (F3,20 = 8.751, P = 0.0007) and Phase II (F3,20 = 19.01, P < 0.0001) followed by Bonferroni post hoc test: YHS vs vehicle, *P < 0.05, **P < 0.01, *** P < 0.001; KO vs WT, N.S., not significant.