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. 2016 Sep 13;11(9):e0162875. doi: 10.1371/journal.pone.0162875

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© 2016 Wang et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 3 — (A) Effects of YHS (200 mg/kg) in WT mice assessed in the von Frey filaments assay after SNL (n = 10). Paw withdraw thresholds were measured 60 minutes after drug administration. Two way ANOVA revealed a significant treatment effect (F_3,36 = 12.81, P < 0.0001) and time effect (F_1,36 = 7.244, P = 0.0107) followed by Bonferroni post hoc test: contralateral vs. ipsilateral, **P < 0.01, *** P < 0.001, N.S., not significant; YHS vs vehicle, ^# P < 0.05. (B) Effects of YHS (200 mg/kg) in D2KO mice assessed in the von Frey filaments assay after SNL (n = 10). Paw withdraw thresholds were measured 60 minutes after drug administration. Two way ANOVA revealed a significant treatment effect (F_3,36 = 17.00, P < 0.0001) and time effect (F_1,36 = 6.340, P = 0.0164) followed by Bonferroni post hoc test: contralateral vs. ipsilateral, *P < 0.05, **P < 0.01; YHS vs vehicle, ^# P < 0.05, N.S., not significant. (C) Paw withdraw threshold (PWT) difference between contralateral (Contra) and ipsilateral (Ipsi) paws in WT and D2KO mice assessed in the von Frey filaments assay 60 minutes after YHS (200 mg/kg) administration (n = 10): t = 2.281, P = 0.0349. Unpaired student t test, KO vs WT, *P < 0.05. (D) Effects of YHS (200 mg/kg) in WT mice assessed in the hot box assay after SNL (n = 10). Paw withdraw latencies were measured 60 minutes after drug administration. Two way ANOVA revealed a significant treatment effect (F_3,36 = 66.27, P < 0.0001), time effect (F_1,36 = 34.40, P < 0.0001) and drug x time interaction (F_3,36 = 19.38, P < 0.0001) followed by Bonferroni post hoc test: contralateral vs. ipsilateral, *P < 0.05, *** P < 0.001; YHS vs vehicle, ^### P < 0.001, N.S., not significant. (E) Effects of YHS (200 mg/kg) in D2KO mice assessed in the hot box assay after SNL (n = 9–10). Paw withdraw latencies were measured 60 minutes after drug administration. Two way ANOVA revealed a significant treatment effect (F_3,34 = 75.99, P < 0.0001), time effect (F_1,34 = 25.25, P < 0.0001) and drug x time interaction (F_3,34 = 6.119, P = 0.0019) followed by Bonferroni post hoc test: contralateral vs. ipsilateral, *** P < 0.001; YHS vs vehicle, ^### P < 0.001, N.S., not significant. (F) Paw withdraw latency (PWL) difference between contralateral (Contra) and ipsilateral (Ipsi) paws in WT and D2KO mice assessed in the hot box assay 60 minutes after YHS (200 mg/kg) administration (n = 9–10): t = 1.394, P = 0.1812. Unpaired student t test, N.S., not significant.