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. 2016 Sep 12;36(19):2440–2450. doi: 10.1128/MCB.01034-15

FIG 1.

FIG 1

Tissue-specific disruption of Epac1 in WAT increases body weight gains and food intake on HFD. (A) Epac1 protein levels in epididymal white adipose tissue (EWAT), hypothalamus, subcutaneous white adipose tissue (SWAT), brown adipose tissue (BAT), preadipocytes, and cardiomyocytes of WT and AEKO mice. (B) Quantification of Epac1 protein expression in various tissues of WT and AEKO mice. (C) Quantification of Epac1 mRNA expression levels in EWAT and isolated macrophages. (D) Body weight changes of WT (n = 8) and AEKO (n = 7) mice on HFD. (E) Average daily food intake of WT (n = 8) and AEKO (n = 7) mice on HFD over 41 days. (F) Body weight changes of WT and AEKO mice on regular chow diet. Data are presented as means ± standard errors of the mean (SEM). *, P < 0.05; ***, P < 0.005; ****, P < 0.001.