FIG 2.

Deletion of Epac1 in WAT downregulates energy expenditure. (A) Energy expenditure of WT and AEKO mice at the age of 5 to 6 weeks measured by O₂ consumption using CLAMS. (B) Average O₂ consumption of WT and AEKO mice. (C) Energy expenditure of WT and AEKO mice at the age of 5 weeks measured by CO₂ production using CLAMS. (D) Average CO₂ production of WT and AEKO mice. (E) The respiratory exchange ratio of WT and AEKO mice. (F) Daily food intake of WT and AEKO mice on regular chow diet and HFD. (G) Spontaneous activity profiles of WT and AEKO mice. (H) Average spontaneous locomotor activity of WT and AEKO mice. Data are means ± SEM. *, P < 0.05.