Asymmetrical structure of various ATPase hexamer models. Structure illustrations of V1-ATPase (adapted from reference 75 with permission of the publisher), TRIP13 (adapted and modified from reference 76 with permission of the publisher), ClpX (adapted and modified from reference 77 with permission of the publisher), MCM helicase (adapted from reference 79 with permission of the publisher), and F1-ATPase (80) are shown as representatives of asymmetrical hexamers. PDB accession numbers are as follows: V1-ATPase, 3VR5; TRIP13, 4XGU; F1-ATPase, 1BMF; ClpX, 4I81. The EM reconstruction of the MCM helicase is deposited in the EMDataBank under accession number EMD-5429.