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. 2016 Sep 12;36(19):2451–2463. doi: 10.1128/MCB.01075-15

FIG 2.

FIG 2

Germ line deletion of Ifrd1 increases bone formation and decreases bone resorption, leading to high bone mass. (A) Strategy and confirmation for the generation of germ line Ifrd1-knockout mice. Higher bone volume in long bones and vertebrae of Ifrd1 knockout mice was found. (B and C) μCT analysis (B) and BV/TV ratios (C) of femurs of WT and Ifrd1 knockout mice at 12 weeks old. (D to H) von Kossa staining (D), BV/TV ratios (E), BFR (F), Ob.S/BS values (G), and Oc.S/BS values (H) of vertebrae of WT and Ifrd1 knockout mice at 12 weeks old (WT, n = 6 to 8; Ifrd1−/−, n = 5 to 8). Asterisks indicate values significantly different from the value obtained for WT mice: *, P < 0.05; **, P < 0.01.