FIG 6.

In vivo replication kinetics and peripheral CD4 depletion. (A and B) Plasma viral loads from animals infected with SIVmac clones (A) or SIVsm clones (B) highlight the consistency of SIVmac infections and the variable viral loads following SIVsm infection. The legend (right) indicates the infecting virus and TRIM5α genotype for each animal. †, euthanasia due to simian-AIDS-defining conditions. (C and D) Longitudinal absolute peripheral blood CD4⁺ T cell counts for SIVmac-infected animals (C) and SIVsm-infected animals (D). (E) Early gut CD4⁺ T cell depletion shown by immunohistochemistry in SIVmac766-infected animals (p106 and p097) and SIVsmCG7G-infected animals (p114 and p116) from preinfection and acute infection (day 28 postinfection). The brown stain is for CD4⁺ cells, and pink staining for myeloperoxidase identifies myeloid cells. Scale bars, 100 μm.