FIG 7.

In vitro replication curves of 4 T/F IMCs (SIVsmCG7G, SIVsmCG7V, SIVmac746, and SIVmac766) and the control clones SIVmac239 and SIVsmE543. Viruses from these clones were used to infect CD8-depleted PBMCs collected from 2 naive rhesus macaques. One macaque (A) possessed a permissive TRIM5α genotype (Q/Q), while the other (B) possessed a restrictive TRIM5α genotype (TFP/TFP). RT activity was measured at days 3, 7, and 10 postinfection, showing significant TRIM5α-specific restriction of SIVsm, but not SIVmac.