FIG 8.

Antiviral activities of other 4-aminoquinoline-based molecules against a B5-resistant mutant. Huh-7 cells were pretreated for 1 h with CQ (A), FQ (B), or B5 (C) before infection with JFH1 or mutant viruses (MOI of 1), and infected cells were in contact with the drug until the end of the experiment. At 30 h postinfection, infected cells were quantified. Results are expressed as percentage of infection in the presence of the solvent. Error bars indicate standard errors of the means from at least three independent experiments. Mutant FY contains E1 mutations F291I and Y297H selected in the presence of B5. Mutant SA contains mutation S327A selected in the presence of FQ (15).