TABLE 1.
B5 inhibits infection with different HCV genotypesa
| Genotype | IC50, μM (mean ± SD)b |
|---|---|
| gt1b | 0.77 ± 0.25 |
| gt2a | 0.91 ± 0.64 |
| gt3a | 2.93 ± 1.24 |
| gt4a | 1.81 ± 0.48 |
| gt5a | 1.15 ± 0.53 |
| gt6a | 1.87 ± 0.99 |
a
The antiviral effect of B5 was tested on JFH1 (gt2a) or chimeric viruses expressing the structural proteins of different genotypes: GT1b(Con1)/JFH1 (gt1b), GT3a(S52)/JFH1 (gt3a), GT4a(ED43)/JFH1 (gt4a), GT5a(SA13)/JFH1 (gt5a), or GT6a(HK6a)/JFH1 (gt6a).
b
IC50s were determined based on the titration of infectious virus released in the supernatant of treated cells.