TABLE 1.
Parameter | Value for correlation with: |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Avidity | gp130 IgG | V1V2 IgG | E660 gp140 IgG | E660 V1V2 IgG | 239 V1V2 IgG | Cyclic V2 IgG | E543 cyclic V2 IgG | Cyclic V2 IgA | Cyclic V2 E543 IgA | E660 gp140 IgA | gp140 IgA | Neutralization |
gp130 rectal IgG | Cyclic V2 rectal IgGc | Cyclic V2 sp act | E543 V2 rectal IgGc | E543 V2 rectal IgAc | V2 rectal IgAc | ADCC |
Phagocytosis | |||
SIVmac251-6 | SIVmac251 (challenge) | Maximum kill | Titer | ||||||||||||||||||||
Correlation coefficient | 0.002 | 0.50 | 0.31 | 0.54 | 0.17 | 0.32 | 0.49 | 0.59 | 0.16 | 0.27 | 0.53 | 0.35 | 0.71 | −0.066 | 0.64 | −0.16 | −0.33 | −0.20 | −0.27 | −0.22 | −0.16 | 0.52 | 0.45 |
P valueb | 0.99 | 0.0004 | 0.031 | 0.0001 | 0.25 | 0.026 | 0.0004 | <0.0001 | 0.27 (MW) | 0.061 (JT) | <0.0001 | 0.014 | <0.0001 | 0.65 | <0.0001 | 0.21 (JT) | 0.049 (MW) | 0.21 | 0.085 (JT) | 0.19 (JT) | 0.26 | 0.0001 | 0.0013 |
No. of samples | 50 | 49 | 49 | 49 | 49 | 49 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 39 | 42 | 48 | 42 | 41 | 41 | 50 | 50 | 50 |
E543 refers to SIVsmE543. Correlation coefficients and P values are Spearman's unless otherwise indicated.
MW, Mann-Whitney test for antibody values of =0 versus >0; JT, Jonckheere-Terpstra test for postvaccination minus prevaccination values of <0 versus =0 versus >0. Significant values (P < 0.05) are in bold; P < 0.004 is significant after correction for multiple comparisons.
Values obtained by subtracting prevaccination from postvaccination results.