FIG 5.

Inhibition of pCREB interaction with p300/CBP interferes with VZV infection of skin xenografts as shown by in vivo imaging. Two xenografts per mouse were infected with VZV expressing firefly luciferase (rOka-R6362FL; 5.7 × 105 PFU/ml) 4 weeks after engraftment and were treated with either DMSO (left) or XX-650-23 (right) daily from 0 to 14 dpi. Mice were imaged from day 7 to day 21 postinfection at the indicated time points. Radiance units (photons per second per square centimeter per steradian) were used to compare the images. The results shown are from one experiment representative of two independent experiments.