FIG 6.

Inhibition of pCREB interaction with p300/CBP interferes with VZV replication in skin xenografts. (A) The bioluminescence signal was quantified by measuring the average radiance inside a region of interest standardized for size over each skin xenograft. The average radiance was plotted against the day postinfection. Treatments received by the mice are indicated on the x axis, and the arrows indicate the last day of treatment. The values obtained at each day were analyzed with unpaired Student t tests, and significantly different values are indicated with asterisks. Shown are means ± SD. (B) Xenografts were harvested 22 days postinfection, and titers were determined by plaque assay. Shown are means ± SD; P = 0.001 (Mann-Whitney, unpaired, nonparametric test).