FIG 8.

Detection of pCREB in lesions in VZV-infected skin xenografts. Human skin xenografts were harvested 22 days postinfection, and sections were stained with mouse anti-VZV-gE antibody (Alexa-488; green) and rabbit anti-pCREB antibodies (Alexa-647; red). Nuclei were detected using Hoechst staining. (A) Skin section from a mouse treated with DMSO for 14 days. (B) Skin section from a mouse treated with XX-650-23 for 14 days. (C) Skin section from a mouse that uninfected, left untreated. (D) Skin section stained with secondary antibodies and Hoechst only.