FIG 3.

Circos plot showing the location of the core 137 variant sites common to all vOka-derived preparations. Vaccine allele frequencies are shown by the length of the red (nonsynonymous), blue (synonymous), and black (noncoding) lines, all overlaid on a backbone (gray) indicating the exact position of the SNP. Triangular headers indicate sites previously identified by Gomi and coworkers (17). The outer band shown the canonical genome structure (UL-IRL-US-TRL) with the IRL and TRL shown in lilac and the R1, R2, R3, R4, R5, and OriS repeat regions shown in black. Forward and reverse coding ORFs are shown as orange blocks. Relevant ORF numbers are indicated around the outside of the plot.