Table 2.
Probe Sets With Some of the Highest Signals in Orbital Adipose Tissue Compared With Uninflamed Controlsa
| Probe Set | Gene Title | Fold Difference | P Value for FDR |
|---|---|---|---|
| 209396_s_at | Chitinase 3–like 1 (cartilage glycoprotein-39) | 93.5 | 1.5 × 10−6 |
| 1555745_a_at | Lysozyme | 93.3 | 8.98 × 10−7 |
| 214677_x_at | Immunoglobulin λ constant 1 (Mcg marker) | 53.5 | 1.84 × 10−4 |
| 224795_x_at | Immunoglobulin κ locus; immunoglobulin kappa constant | 45.0 | 2.00 × 10−4 |
| 217022_s_at | Immunoglobulin heavy locus; immunoglobulin heavy constant α 1; immunoglobulin heavy constant α 2 (A2m marker) | 42.8 | 1.22 × 10−4 |
| 203915_at | Chemokine (C-X-C motif) ligand 9 | 35.0 | 6.22 × 10−5 |
| 215121_x_at | Immunoglobulin λ light chain-like; immunoglobulin λ constant 1 (Mcg marker); immunoglobulin λ variable 1–44 | 34.8 | 3.47 × 10−4 |
| 216491_x_at | Immunoglobulin heavy constant μ | 34.2 | 7.80 × 10−5 |
| 212671_s_at | Major histocompatibility complex, class II, DQ α 1, DQ α 2, DQ α 1 chain–like | 30.9 | 1.05 × 10−5 |
| 209875_s_at | Secreted phosphoprotein 1 | 29.5 | 2.39 × 10−3 |
| 1555756_a_at | C-type lectin domain family 7, member A | 28.9 | 7.07 × 10−5 |
| 202834_at | Angiotensinogen (serpin peptidase inhibitor, clade A, member 8) | 28.3 | 9.29 × 10−5 |
| 219386_s_at | SLAM family member 8 | 25.5 | 7.40 × 10−6 |
| 219159_s_at | SLAM family member 7 | 24.7 | 1.16 × 10−4 |
| 222838_at | SLAM family member 7 | 23.3 | 2.12 × 10−5 |
| 211429_s_at | Serpin peptidase inhibitor, clade A (α-1 antiproteinase, antitrypsin), member 1 | 21.1 | 4.50 × 10−5 |
| 209696_at | Fructose-1,6-bisphosphatase 1 | 18.4 | 1.63 × 10−7 |
| 205890_s_at | GABA B receptor, 1; ubiquitin D | 18.3 | 7.05 × 10−5 |
| 203936_s_at | Matrix metallopeptidase 9 (gelatinase B, 92-kDa gelatinase, 92-kDa type IV collagenase) | 17.7 | 1.17 × 10−6 |
| 209201_x_at | Chemokine (C-X-C motif) receptor 4 | 17.4 | 3.32 × 10−5 |
Abbreviations: FDR, false discovery rate; GABA, γ-aminobutyric acid; SLAM, signaling lymphocyte activation molecule.
a
Only the probe with the highest fold difference for a given gene is reported. Only probe sets with adequate annotation are included. The complete list of probe sets is reported in eTable 1 in the Supplement.