Table 3.
Clinical Features of EoE Cases vs Controls (individuals without EoE):
| Diagnoses | EoE Cases, n (%) | Controls, n (%) |
|---|---|---|
| GI Diagnoses1 | ||
| GERD | 5120 (65.3) | 7,420,150 (10.2) |
| Heartburn | 600 (7.6) | 224,260 (0.7) |
| Dysphagia | 6180 (78.8) | 673,390 (2.2) |
| Esophageal stricture | 1960 (25) | 103,470 (0.3) |
| Chest pain | 2110 (26.9) | 3,293,360 (10.7) |
| Foreign body in esophagus |
920 (11.7) | 28,230 (0.1) |
| Nausea and vomiting | 1510 (19.3) | 1,216,320 (3.9) |
| Esophageal web | 420 (5.4) | 19,930 (0.06) |
| FTT (Failure to thrive) | 270 (3.4) | 144,600 (0.5) |
| Esophageal perforation | 60 (0.8) | 2300 (0.007) |
| Barrett’s esophagus | 380 (4.8) | 107,010 (0.3) |
| Eosinophilic gastritis | 100 (1.3) | 480 (0.002) |
| Eosinophilic colitis | 30 (0.4) | 540 (0.002) |
| Allergic Diagnoses2 | ||
| Allergic condition | 5260 (67.1) | 7,802,410 (25.3) |
| Drug allergy | 3130 (39.9) | 5,802,650 (18.9) |
| Rhinitis | 2750 (35.1) | 2,214,140 (7.2) |
| Asthma | 2290 (29.2) | 2,383,590 (7.8) |
| Sinusitis | 2270 (29.0) | 2,538,420 (8.3) |
| Dermatitis | 2060 (26.3) | 2,482,670 (8.0) |
| Food allergy | 1590 (20.3) | 646,170 (2.1) |
| Eczema | 1490 (19.0) | 1,624,530 (5.3) |
| Urticaria | 380 (4.8) | 353,600 (1.1) |
| Medications | ||
| Antihistamines | 5500 (70.2) | |
| H2RB | 2020 (25.8) | |
| Topical form corticosteroids |
1300 (16.6) |
1
p-values (by Pearson Chi-square test) for all GI Diagnoses were <0.0001.
2
p-values (by Pearson Chi-square test) for Allergies Diagnoses were <0.0001.