Table 4.
Clinical Features of Adults with EoE (aged 18 yrs and above) and Children with EoE (aged under 18 yrs):
| Diagnoses | Adults, n (%) | Children, n (%) |
|---|---|---|
| GI Diagnoses3 | ||
| GERD | 4340 (65.9) | 780 (62.4) |
| Heartburn | 550 (8.3) | 50 (4.0) |
| Dysphagia | 3810 (57.8) | 370 (29.6) |
| Esophageal stricture | 1910 (29.0) | 50 (4.0) |
| Chest pain | 2000 (30.4) | 110 (8.8) |
| Foreign body in esophagus |
860 (13.0) | 60 (4.8) |
| Nausea and vomiting | 970 (14.7) | 200 (16.0) |
| Esophageal web | 410 (6.2) | 20 (1.6) |
| FTT (Failure to thrive) | 50 (0.8) | 210 (16.8) |
| Esophageal perforation4 |
50 (0.8) | 0 (0.0) |
| Barrett’s esophagus5 | 380 (5.8) | 0 (0.0) |
| Eosinophilic gastritis | 70 (1.1) | 30 (2.4) |
| Eosinophilic colitis | 20 (0.3) | 10 (0.8) |
| Allergic Diagnoses6 | ||
| Allergic condition | 4320 (65.6) | 940 (75.2) |
| Drug allergy | 2780 (42.2) | 350 (28.0) |
| Food allergy | 980 (14.9) | 610 (48.8) |
| Rhinitis | 2230 (33.8) | 520 (41.6) |
| Asthma | 1750 (26.6) | 530 (42.4) |
| Sinusitis | 1960 (29.7) | 310 (24.8) |
| Dermatitis | 1530 (23.2) | 530 (42.4) |
| Eczema | 1080 (16.4) | 420 (33.6) |
| Urticaria | 280 (4.2) | 100 (8.0) |
| Medications | ||
| Antihistamines | 4530 (68.7) | 970 (77.6) |
| H2RB | 1650 (25.0) | 380 (30.4) |
| Topical form corticosteroids |
1030 (15.6) | 270 (21.6) |
3
p-values (by Pearson Chi-square test) for all GI Diagnoses were <0.0001 except for GERD (p=0.019), nausea and vomiting (p=0.24) and eosinophilic colitis (p=0.009).
4
Esophageal perforation and
5
Barrett’s esophagus: These associated diagnoses had positive events in adults and zero events in children and thus tests of statistical significance were not applied to these.
6
p-values (by Pearson Chi-square test) for all Allergies Diagnoses were <0.0001 except for sinusitis (p=0.0004).