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. Author manuscript; available in PMC: 2017 Sep 21.
Published in final edited form as: Chem Soc Rev. 2016 Jul 11;45(18):4929–4952. doi: 10.1039/c5cs00911a

Fig. 15.

Fig. 15

Active, GTP-bound Ras interacts with downstream effector proteins. Most effector proteins interact with the effector-binding region or switch I region (dashed circle) on the protein through their Ras binding domains (RBDs) or Ras-associating (RA, also known as RBD) domains. RafRBD (pink, PDB ID: 4G0N), PI3Kγ (brown, PDB ID: 1HE8), RalGDS-RBD (olive, PDB ID 1LFD), PLCε-RBD (wheat, PDB ID: 2C5L), NORE1A-RA (orange, PDB ID: 3DDC), Byr2RBD (palegreen, PDB ID: 1K8R), and Grb14 (lightblue, PDB ID: 4K81) bind to the effector-binding region on H-Ras–GppNHp (cyan, PDB ID: 5P21). In the H-Ras–RalGDS complex, the crystal contains two molecules of each H-Ras and RalGDS-RBD in the asymmetric unit.