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. Author manuscript; available in PMC: 2016 Oct 1.
Published in final edited form as: Hum Mutat. 2016 Aug 8;37(10):1004–1012. doi: 10.1002/humu.23036

Figure 3. Estimation of the increased mononucleotide repeat mutational load in tumors with microsatellite instability (MSI).

Figure 3

(A) Average mutations per tumor sample in 71 non-coding mononucleotide runs for microsatellite stable (MSS) and MSI+ EECs. Error bars are s.e.m. (B) Distribution of non-coding mutations normalized to the number of samples and number of mononucleotide repeat loci sequenced shows an increase in mutability with increasing mononucleotide run length. Error bars are s.e.m. (C) Fold increase in non-coding strand-slippage mutations for MSI+ compared to MSS tumors. Error bars are s.e.m.