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Treatment related toxicities
| Grade 3 | Grade 4 | |||||
|---|---|---|---|---|---|---|
| Category | Bev + lomustine 90 mg/m2 | Bev + lomustine 75 mg/m2 | Bev alone | Bev + lomustine 90 mg/m2 | Bev + lomustine 75 mg/m2 | Bev alone |
| Leukopenia | 4 | 1 | 0 | 1 | 0 | 0 |
| Neutropenia | 3 | 1 | 1 | 1 | 0 | 0 |
| Thrombocytopenia | 4 | 2 | 0 | 2 | 0 | 0 |
| Lymphopenia | 6 | 6 | 8 | 3 | 1 | 0 |
| Fatigue | 0 | 1 | 4 | 0 | 0 | 0 |
| CNS Hemorrhage | 0 | 0 | 0 | 0 | 0 | 0 |
| HTN | 1 | 0 | 2 | 0 | 0 | 0 |
| VTE | 0 | 0 | 0 | 1 | 0 | 0 |
| GI perforation | 0 | 0 | 1 | 0 | 0 | 0 |
| CNS Ischemia | 0 | 0 | 0 | 0 | 0 | 2 |
