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. Author manuscript; available in PMC: 2017 Sep 12.
Published in final edited form as: Integr Biol (Camb). 2016 Aug 1;8(9):918–928. doi: 10.1039/c6ib00046k

Figure 4. Two types of cell division in the intestinal epithelium.

Figure 4

(A) Cross-section of the intestine at E14.5. A subset of dividing cells (KI67, red) are associated with a T-shaped invagination of the apical surface (arrow). Other rounded mitotic cells are adjacent to a flat or V-shaped (asterisk) surface indentation. Apical surface is stained with antibodies to EZRIN (green). Clusters are also stained with antibodies to PDGFRα (red). Scale bar = 50 µm. (B, C) Confocal images of dividing cells (KI67 or pHH3, red) adjacent to a (B) V-shaped (asterisk) or (C) T-shaped (arrow) apical indentations (EZRIN, green). This T-shaped indentation is reminiscent of internalized cell rounding described in the Drosophila tracheal placode.21 Scale bar = 5 µm.