Table 2.

Independent predictors of disease progression markers.

Outcome 1 year change in:	Women (ref: Men)	Coefficient of change [standard error]				Disease duration	# of comorbidities
		Hoehn and Yahr (ref: Stage 1)			Age
		4&5	3	2
PDQ-39
Summary score	0.396 [0.322]	−1.555 [0.842]	0.393 [0.589]	−0.120 [0.515]	0.068 *** [0.017]	−0.004 [0.027]	−0.269* [0.121]
Mobility	0.293 [0.228]	−2.648 ***[0.595]	0.200 *** [0.416]	0.226 ***[0.364]	0.067 *** [0.012]	0.050** [0.019]	−0.199 [0.086]
ADL	0.255 [0.132]	−0.052 [0.344]	0.203 [0.241]	−0.138 [0.211]	0.030 *** [0.007]	−0.006 [0.011]	−0.080 [0.050]
Emotional well-being	0.128 [0.118]	−0.277 [0.310]	0.277 [0.216]	0.153 [0.189]	0.026*** [0.006]	0.009 [0.010]	−0.095* [0.045]
Stigma	0.009 [0.087]	−0.30 [0.227]	0.002 [0.159]	0.015 [0.139]	0.006 [0.005]	−0.11 [0.007]	0.004 [0.033]
Social support	0.039 [0.056]	−0.358* [0.147]	0.030* [0.103]	−0.041* [0.090]	0.003 [0.003]	0.000 [0.005]	−0.010 [0.021]
Cognition	0.059 [0.081]	−0.287 [0.213]	0.137 [0.148]	−0.036 [0.130]	0.009* [0.004]	−0.006 [0.007]	−0.029 [0.031]
Pain	−0.004 [0.077]	−0.251 [0.202]	−0.299 [0.141]	−0.199 [0.124]	0.002 [0.004]	−0.014* [0.006]	−0.042 [0.029]
# of medications	0.004 [0.027]	−0.130** [0.071]	−0.097** [0.050]	−0.032**[0.044]	0.001 [0.001]	−0.014***[0.002]	−0.011 [0.010]
Standardized TUG	−0.048 [0.025]	−0.151* [0.070]	0.051* [0.045]	0.052* [0.039]	0.003* [0.001]	0.008 *** [0.002]	0.005 [0.010]
Verbal fluency	0.155 [0.155]	−0.885* [0.407]	−0.429* [0.282]	−0.058* [0.247]	−0.018* [0.008]	−0.032* [0.013]	−0.062 [0.058]
Delayed recall	0.094* [0.042]	−0.129 [0.110]	−0.015 [0.076]	0.058 [0.067]	−0.008 ***[0.002]	−0.004 [0.004]	−0.037* [0.016]

Note. Values represent coefficient of change for each predictor variable. Each model controls for all other listed variables.

^*p < 0.05;

^**p < 0.01;

^***p < 0.001