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. 2016 Sep 13;3(1):22. doi: 10.1186/s40634-016-0060-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 2 — Factors regulating Wnt signaling in OA osteoblasts (modification from the original drawing representing the canonical Wnt route adapted from Baron & Kneissel 2013). APC, Adenomatous polyposis coli; DKK2, Dickkopf-related protein 2; DVL, Dishevelled protein; FZD, frizzled receptor; GSK3, glycogen synthase kinase 3; HGF, hepatocyte growth factor; LEF, lymphoid enhancing factor; LPR, lipoprotein receptor-related protein; R-Spo2, R-spondin 2; TCF, T-cell factor; TGF-β, transforming growth factor beta