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. 2016 Sep 13;3(1):22. doi: 10.1186/s40634-016-0060-6

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© The Author(s). 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 6 — Cell-matrix interface in OA. Interactions between membrane sensors/receptors at the surface of chondrocytes become altered during OA, leading to abnormal signalling and activation of OA-related pathways via integrins (a), syndecan-4 (b), DDR-2 (c), and CD44 (d)