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Invasive and non-invasive models
| Invasive models | Non-invasive models | |
|---|---|---|
| Advantages | rapid induction, high reproducibility, readily available, widely described systems | rapid induction, high reproducibility, low infection risk, long time frame of OA changes, allowing for early evaluation and intervention |
| Limitations | risk of infection, expertise needed, early changes often, undetectable because of rapid induction | not readily available, expertise needed, scarce literature |
