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. 2016 Jul 1;5(8):635–645. doi: 10.1016/j.molmet.2016.06.012

Figure 4.

Figure 4

Mitochondrial oxidative capacity in human skeletal muscle displays a day-night rhythm. (A) ADP-stimulated respiration of permeabilized muscle fibers upon a lipid substrate (state 3 MO); fueled by complex I-linked substrates (state 3 MOG) and upon parallel electron input into complex I and II (state 3 MOGS). (B) Maximally uncoupled respiration upon FCCP (State U). M, malate; O, octanoylcarnitine; G, glutamate; S, succinate. Data represents oxygen consumption per mg wet weight per second and is depicted as mean ± SEM. *p < 0.05 for the effect of time in all states. #p < 0.05 vs 1 PM for Bonferroni-adjusted post-hoc analysis.