Table 1.
Acute effects of leptin and insulin on VMH SF1 neurons and the role of specific p110 catalytic subunits.
| sf1-cre/wildtype (13.9 ± 0.4 pF, n = 130) |
sf1-cre/p110αflox/flox (11.8 ± 1.1 pF, n = 25) |
sf1-cre/p110βflox/flox (14.0 ± 0.7 pF, n = 19) |
sf1-cre/p110αflox/flox, p110βflox/flox (10.1 ± 0.5 pF, n = 20) |
|||||
|---|---|---|---|---|---|---|---|---|
| Leptin | Insulin | Leptin | Insulin | Leptin | Insulin | Leptin | Insulin | |
| Depolarized | 14 (17.5%) | 0 (0%) | 1 (5.0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) | 0 (0%) |
| Hyperpolarized | 14 (17.5%) | 11 (23.4%) | 3 (15.0%) | 3 (23.1%) | 2 (11.1%) | 1 (6.3%) | 0 (0%) | 0 (0%) |
| No response | 52 (65.0%) | 36 (76.6%) | 16 (80.0%) | 10 (76.9%) | 16 (88.9%) | 15 (93.9%) | 18 (100.0%) | 17 (100.0%) |
| Recorded | 80 | 47 | 20 | 13 | 18 | 16 | 18 | 17 |