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. 2016 Jun 15;5(8):615–625. doi: 10.1016/j.molmet.2016.06.005

Figure 4.

Figure 4

Effects of miR-125b-5p over-expression and inhibition. hMADS adipocytes transfected with miR-125b-5p mimics (A, B) or miR-125b-5p LNA inhibitor (C, D) or their respective control at day 14 and oxygen consumption measurements (A and C) were performed at day 18. Plots show mitochondrial OCR, and histograms correspond to mitochondrial respiration values. Mitochondrial DNA content was quantified by qPCR upon over-expression or inhibition of miR-125b-5p (B and D), as described in material and methods section. Plots and histograms display mean ± SEM, *, **: p < 0.05, data are from 3 independent experiments (4 replicates per experiment). *: mimic ctr vs. mimic miR-125b-5p; **: white vs. brite.