Table 2.

Evaluations of γδ T cell therapy in OS.

Ancillary therapy	Study type	Comment
None	In vitro (65)	Markedly enhanced cytotoxicity against the antigen-pulsed tumor cells as compared with untreated tumor cells
ZA	In vitro (75)	Potent antitumor activity and the enhanced immunosensitivity of OS cell lines to γδ T cells
IFN-γ	In vitro (22)	Enhancement of susceptibility of tumor cell lines, HOS and U2OS, to the cytotoxicity of γδ T cells
ZA	In vitro and in vivo (78)	More efficient ability to inhibit tumor growth and potent antitumor activity
Trastuzumab + ZA	In vitro (77)	Enhancement of cytotoxicity of γδ T cells against ZA-sensitized OS cells