Zhao et al. [27]
|
Sprague–Dawley (SD) rats |
6–8 weeks old |
400 ll of 2.5 mg/ml TNBS |
50% |
1 |
7 d |
marked decrease in both the mRNA and protein expression |
Cury et al. [28]
|
Wistar rats |
(240–280 g) |
25 mg TNBS (0.6 ml) |
50% |
1 |
12 d |
calprotectin levels correlate with biochemical and histological markers of inflammation |
Vermeulen et al. [29]
|
Wistar rats |
(180–220 g) |
7.5 mg |
40% |
1 |
– |
TRPV1 and TRPA1 may be promising targets in pain modulation. |
Abad et al. [30]
|
BALB/c mice |
6–8 weeks |
3-mg |
50% |
2 |
3–10 d |
VIP has beneficial prophylactic and therapeutic effects in TNBS-induced colitis |
Petrella et al. [31]
|
Wistar rats |
(200–250 g) |
60 mg/kg |
|
1 |
4 d |
Low doses of N/OFQ significantly decrease the colonic inflammatory profile |
Chen et al. [32]
|
Rats; |
|
0.6 mL |
50% |
1 |
1–21 d |
NF-κB also regulates ICAM-1 expression during colonic inflammation. Pretreatment of PDTC may attenuate the inflammation development. |
Fitzpatrick et al. [33]
|
Wistar rats |
Neonatal rats-3w. |
8 to 32 mg |
40% |
1, 3, or 4 |
23, 35, 48, and 59 d |
This chronic TNBS model may be useful for studying the development of inflammation and fibrosis in preadult animals |
Rivera et al. [34]
|
Sprague-Dawley rats |
(220–265 g) |
30 mg |
50% |
1 |
3 d |
9 of 10 critical genes identified by DNA microarray. |
Pohlmann et al. [35]
|
Wistar rats |
(297 5 g; mean) |
17.5 mg |
30% |
1 |
10 d |
this technique could provide useful information for the evaluation of potential new treatments for IBD |
Charpentier et al. [36]
|
Sprague–Dawley rats |
(200–250 g) |
25 mg |
50% |
1 |
2 d |
Minimal bowel wall thickness and wall signal intensity on T2w images were associated with histological score |
Foligne et al. |
BALB/C mice |
7–8 weeks |
50 to 150 mg/kg |
50% |
1 |
2 d |
The use of the model as described above allows the construction of long-term databases which can serve as a reference for future strain comparisons |
Natah et al. [37]
|
Sprague–Dawley rats |
(250–300 g) |
30 mg |
50% |
1 |
1, 2, 3, 7 and 21 d |
colitis transiently increased permeability to sodium fluorescein and led to a mild disruption of BBB |
Motavallian et al. |
Wistar rats |
(200 ± 20 g) |
10 mg |
50% |
1 |
6 d |
administration of cisapride, a 5HT4 receptor agonist, does not aggravate the severity of colonic injuries in TNBS-induced colitis in rat |
El-Salhy et al. [38]
|
Wistar rats |
(166–246 g) |
25 mg |
50% |
1 |
3 d |
colonoscopy provides a reliable method for following up |
Lohman et al. [39]
|
Wistar rats |
8–9 weeks |
80 mg/kg |
50% |
1 |
8 d |
The current results connect PAR2 activation to -tryptase release and mast cells in the pathogenesis of TNBS colitis |
Yue et al. [40]
|
Sprague-Dawley rats |
(300–350 g) |
25 mg/ml |
50% |
1 |
1 d |
local elevated level of peroxynitrite is a major contributor to colon epithelial apoptosis |
Pilichos et al. [41]
|
Wistar rats |
300-450 g |
60 mg/ml |
30% |
1 |
10 d |
NOS inhibitors might prove to be promising therapeutic agents for IBD |
Brenna et al. [42]
|
Sprague-Dawley rats |
8 weeks |
30 mg/ml |
50% |
1 |
12 d |
Endoscopy with biopsies in TNBS-colitis is useful to follow temporal changes of inflammation |