Table 1.
The associations between MAPKs and clinicopathological variables in breast cancer
| Pan ERK1/2 | Nuclear p-ERK1/2 | Cytoplasmic-p-ERK1/2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | |
| Grade | |||||||||
| 1 | 85 (14) | 99 (17) | 0.031 | 54 (9) | 118 (20) | <0.0001 | 52 (10) | 119 (20) | 0.001 |
| 2 | 199 (32) | 203 (36) | 156 (28) | 241 (41) | 172 (32) | 220 (36) | |||
| 3 | 338 (54) | 268 (47) | 352 (63) | 235 (39) | 310 (58) | 271 (44) | |||
| Lymph node stage | |||||||||
| 1 | 379 (61) | 343 (60) | 0.085 | 343 (61) | 118 (20) | NS | 313 (58) | 384 (63) | NS |
| 2 | 180 (29) | 188 (33) | 170 (30) | 241 (41) | 164 (31) | 178 (29) | |||
| 3 | 63 (10) | 40 (7) | 49 (9) | 235 (39) | 57 (11) | 48 (8) | |||
| Tumour size | |||||||||
| <2 CM | 290 (47) | 301 (53) | 0.029 | 242 (43) | 324 (54) | <0.0001 | 222 (42) | 336 (55) | <0.0001 |
| >2CM | 334 (53) | 269 (47) | 321 (57) | 272 (46) | 312 (58) | 277 (45) | |||
| Lymphovascular invasion | |||||||||
| No | 399 (65) | 381 (67) | 357 (64) | 399 (67) | 322 (61) | 425 (70) | 0.001 | ||
| Definite | 219 (35) | 190 (33) | NS | 202 (36) | 192 (33) | NS | 210 (39) | 181(30) | |
| NPI | |||||||||
| GPG | 170 (28) | 183 (34) | 0.015 | 121 (23) | 209 (37) | <0.0001 | 122 (24) | 205 (35) | <0.0001 |
| MPG | 324 (54) | 293 (54) | 314 (59) | 293 (51) | 286 (56) | 317 (54) | |||
| PPG | 106 (18) | 66 (12) | 101 (19) | 70 (12) | 104 (20) | 64 (11) | |||
| Pan JNK1/2 | p-JNK1/2 | Pan p38 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | |
| Grade | |||||||||
| 1 | 100 (17) | 104 (19) | NS | 26 (11) | 131 (16) | <0.0001 | 26 (11) | 131 (16) | 0.002 |
| 2 | 216 (36) | 168 (32) | 45 (20) | 308 (37) | 45 (20) | 308 (37) | |||
| 3 | 277 (47) | 260 (49) | 156 (69) | 388 (50) | 156 (69) | 388 (50) | |||
| Lymph node stage | |||||||||
| 1 | 398 (65) | 356 (65) | NS | 140 (62) | 498 (60) | NS | 140 (62) | 498 (60) | NS |
| 2 | 169 (8) | 150 (27) | 66 (29) | 260 (32) | 66 (29) | 260 (32) | |||
| 3 | 46 (7) | 42 (8) | 21 (9) | 69 (8) | 21 (9) | 69 (8) | |||
| Tumour size | |||||||||
| <2 CM | 283 (50) | 274 (55) | 0.079 | 93 (40) | 427 (52) | 0.003 | 93 (40) | 427 (52) | NS |
| >2 CM | 286 (50) | 223 (45) | 137 (60) | 401 (48) | 137 (60) | 401 (48) | |||
| Lymphovascular invasion | |||||||||
| No | 376 (67) | 344 (69) | NS | 153 (67) | 540 (66) | NS | 153 (67) | 540 (66) | NS |
| Definite | 187 (33) | 152 (31) | 76 (33) | 282 (34) | 76 (33) | 282 (34) | |||
| NPI | |||||||||
| GPG | 192 (33) | 181 (35) | NS | 47 (21) | 255 (32) | 0.002 | 47 (21) | 255 (32) | 0.013 |
| MPG | 303 (53) | 266 (52) | 132 (60) | 435 (55) | 132 (60) | 435 (55) | |||
| PPG | 79 (14) | 69 (13) | 42 (19) | 103 (13) | 42 (19) | 103 (13) | |||
| p-p38 | p–C-JUN | p-ATF2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | |
| Grade | |||||||||
| 1 | 120 (13) | 82 (21) | <0.0001 | 62 (14) | 135 (16) | <0.0001 | 114 (12) | 81 (24) | <0.0001 |
| 2 | 293 (31) | 166 (43) | 119 (26) | 313 (38) | 303 (32) | 139 (42) | |||
| 3 | 525 (56) | 142 (36) | 268 (60) | 380 (46) | 539 (56) | 114 (34) | |||
| Lymph node stage | |||||||||
| 1 | 550 (59) | 261 (67) | 0.008 | 266 (59) | 517 (62) | NS | 571 (60) | 208 (62) | NS |
| 2 | 310 (33) | 96 (24) | 143 (32) | 251 (30) | 311 (32) | 92 (28) | |||
| 3 | 78 (8) | 34 (9) | 40 (9) | 61 (8) | 74 (8) | 35 (10) | |||
| Tumour size | |||||||||
| <2 CM | 423 (45) | 225 (58) | <0.0001 | 206 (46) | 421 (51) | 0.080 | 451 (47) | 173 (52) | NS |
| >2 CM | 517 (55) | 166 (42) | 245 (54) | 408 (49) | 507 (53) | 162 (48) | |||
| Lymphovascular invasion | |||||||||
| No | 602 (65) | 284 (73) | 0.002 | 278 (62) | 566 (69) | 0.015 | 611 (64) | 234 (71) | 0.032 |
| Definite | 332 (35) | 104 (27) | 171 (38) | 258 (31) | 344 (36) | 98 (29) | |||
| NPI | |||||||||
| GPG | 235 (26) | 159 (43) | <0.0001 | 114 (26) | 264 (33) | 0.001 | 240 (26) | 132 (41) | <0.0001 |
| MPG | 508 (57) | 177 (47) | 238 (55) | 426 (54) | 530 (58) | 143 (45) | |||
| PPG | 156 (17) | 38 (10) | 84 (19) | 100 (13) | 149 (16) | 44 (14) | |||
p values in bold denote significant ones (<0.050), borderline: (0.05–0.09), NS: >0.09) and the same in all tables
NPI Nottingham prognostic index, GPG good prognostic group, MPG moderate prognostic group, PPG poor prognostic group