Table 3.
Associations between MAPK and biological markers in ER-positive tumours
| Pan ERK1/2 | N-p-ERK1/2 | C-p-ERK1/2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | |
| HER2 | |||||||||
| Negative | 379 (89) | 407 (92) | NS | 315 (87) | 440 (93) | 0.005 | 337 (90) | 409 (91) | NS |
| Positive | 46 (11) | 37 (8) | 47 (13) | 34 (7) | 38 (10) | 42 (9) | |||
| KI67-LI | |||||||||
| Low | 179 (50) | 190 (52) | NS | 137 (45) | 216 (55) | 0.005 | 141 (46) | 211 (55) | 0.010 |
| High | 180 (50) | 174 (4.8) | 171 (55) | 175 (45) | 169 (54) | 170 (45) | |||
| P53 | |||||||||
| Negative | 325 (77) | 364 (82) | 0.093 | 282 (79) | 368 (79) | NS | 291 (78) | 351 (79) | NS |
| Positive | 96 (23) | 81 (18) | 76 (21) | 99 (21) | 81 (22) | 92 (21) | |||
| BCL2 | |||||||||
| Negative | 101 (33) | 81 (23) | 0.005 | 105 (36) | 87 (25) | 0.001 | 95 (33) | 95 (27) | NS |
| Positive | 206 (67) | 269 (77) | 186 (64) | 267 (75) | 191 (67) | 254 (73) | |||
| Pan JNK1/2 | p-JNK1/2 | Pan p38 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | |
| HER2 | |||||||||
| Negative | 386 (91) | 313 (90) | NS | 115 (87) | 553 (91) | NS | 434 (92) | 328 (90) | NS |
| Positive | 36 (9) | 33 (10) | 17 (13) | 57 (9) | 35 (8) | 36 (10) | |||
| KI67-LI | |||||||||
| Low | 185 (53) | 152 (54) | NS | 48 (44) | 265 (53) | 0.098 | 208 (53) | 158 (52) | NS |
| High | 164 (47) | 127 (46) | 61 (56) | 237 (47) | 187(47) | 144 (48) | |||
| P53 | |||||||||
| Negative | 338 (80) | 267 (7.8) | NS | 108 (83) | 475 (78) | NS | 373 (81) | 295 (81) | NS |
| Positive | 83 (20) | 76 (22) | 22 (17) | 131 (22) | 88 (19) | 69 (19) | |||
| BCL2 | |||||||||
| Negative | 85 (27) | 84 (31) | NS | 36 (33) | 131 (28) | NS | 105 (31) | 66 (24) | 0.057 |
| Positive | 231 (73) | 186 (69) | 73 (67) | 342 (72) | 237 (69) | 211 (76) | |||
| p-p38 | p–C-JUN | p-ATF2 | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | Low N (%) | High N (%) | p value | |
| HER2 | |||||||||
| Negative | 593 (88) | 283 (95) | 0.001 | 273 (89) | 563 (90) | NS | 594 (89) | 256 (94) | 0.010 |
| Positive | 78 (12) | 15 (5) | 32 (11) | 59 (10) | 73 (11) | 15 (6) | |||
| KI67-LI | |||||||||
| Low | 264 (47) | 147 (60) | 0.001 | 113 (44) | 277 (54) | 0.011 | 256 (47) | 136 (58) | 0.003 |
| High | 295 (53) | 97 (40) | 143 (56) | 237 (46) | 292 (53) | 97 (42) | |||
| P53 | |||||||||
| Negative | 533 (80) | 236 (79) | NS | 248 (81) | 488 (79) | NS | 523 (79) | 523 (79) | NS |
| Positive | 135 (20) | 61 (21) | 58 (19) | 128 (21) | 140 (21) | 140 (21) | |||
| BCL2 | |||||||||
| Negative | 162 (31) | 50 (23) | 0.026 | 71 (30) | 136 (29) | NS | 153 (29) | 55 (27) | NS |
| Positive | 360 (69) | 168 (77) | 163 (70) | 333 (71) | 368 (71) | 151 (73) | |||