Table 3.
Univariate and multivariate analyses of factors that may affect overall survival of HB-HCC patients with PVTT
| Risk factor | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95 % CI | p value | HR | 95 % CI | p value | |
| Gender (M/F) | 0.773 | 0.463 ~ 1.290 | 0.324 | |||
| Age (Y) | 1.003 | 0.987 ~ 1.019 | 0.725 | |||
| Type of PVTT (I + II/III) | 0.311 | 0.218 ~ 0.444 | 0.000 | 0.310 | 0.212 ~ 0.453 | 0.000 |
| Response to PVTT | 0.312 | 0.218 ~ 0.445 | 0.000 | 0.503 | 0.338 ~ 0.748 | 0.001 |
| HBV DNA(IU/ml,<104/≥104 | 0.738 | 0.526 ~ 1.036 | 0.079 | 0.965 | 0.680 ~ 1.370 | 0.841 |
| APS (+/-) | 1.979 | 1.353 ~ 2.894 | 0.000 | 2.137 | 1.441 ~ 3.170 | 0.000 |
| Child-Pugh class, A/B | 0.892 | 0.637 ~ 1.249 | 0.506 | |||
| ECOG, 0/1 + 2 | 0.480 | 0.336 ~ 0.685 | 0.000 | 0.810 | 0.537 ~ 1.220 | 0.313 |
| Number of tumor, <3 / ≥3 | 0.721 | 0.515 ~ 1.010 | 0.057 | 0.763 | 0.510 ~ 1.143 | 0.190 |
| Tumor size (cm), <7 / ≥7 | 0.796 | 0.569 ~ 1.114 | 0.184 | 0.817 | 0.577 ~ 1.156 | 0.254 |
| WBC (109/L), <4/≥4 | 1.078 | 0.754 ~ 1.541 | 0.680 | |||
| Hemoglobin (g/L), <100/≥100 | 1.120 | 0.688 ~ 1.823 | 0.649 | |||
| Platelet count (109/L), <100/≥100 | 1.016 | 0.719 ~ 1.436 | 0.929 | |||
| TBIL (μmol/L), <20/≥20 | 0.791 | 0.555 ~ 1.126 | 0.194 | 0.943 | 0.655 ~ 1.356 | 0.750 |
| Albumin(g/L, <35/≥35 | 0.836 | 0.595 ~ 1.173 | 0.300 | |||
| ALT (U/L), <35/≥35 | 1.152 | 0.819 ~ 1.622 | 0.417 | |||
| GGT (U/L), <60/≥60 | 1.163 | 0.827 ~ 1.636 | 0.385 | |||
| AFP (ng/mL), <400/≥400 | 0.842 | 0.599 ~ 1.184 | 0.323 | |||
| Treatment modality | 0.405 | 0.267 ~ 0.615 | 0.000 | 0.405 | 0.267 ~ 0.615 | 0.000 |