Table 2.
Statistical analysis of Peak Flow Expiratory Rate in the morning and evening in the PD analysis set.
| Morning | QAW039 | Placebo | Treatment difference QAW039-placebo |
|---|---|---|---|
| Day | |||
| 1 | 389.6 (377.9, 401.4) | 382.8 (371.1, 394.4) | 6.9 (−9.7, 23.4)NS |
| 2 | 395.0 (382.9, 407.1) | 398.8 (387.5, 410.0) | −3.8 (−20.3, 12.8)NS |
| 7 | 394.4 (382.9, 405.9) | 388.6 (377.2, 400.0) | 5.8 (−10.4, 22.0)NS |
| 14 | 393.3 (381.4, 405.2) | 389.8 (378.4, 401.2) | 3.5 (−13.0, 20.0)NS |
| 21 | 394.1 (381.9, 406.3) | 391.5 (379.9, 403.1) | 2.6 (−14.3, 19.5)NS |
| 28 | 378.6 (366.3, 391.0) | 382.8 (371.3, 394.4) | −4.2 (−21.1, 12.7)NS |
| Evening | QAW039 | Placebo | Treatment difference QAW039-placebo |
| Day | |||
| 1 | 395.8 (382.4, 409.2) | 390.8 (378.6, 403.0) | 4.9 (−13.1, 23.0)NS |
| 2 | 420.9 (407.7, 434.1) | 407.5 (394.4, 420.7) | 13.4 (−5.3, 32.0)NS |
| 7 | 402.9 (388.9, 416.9) | 394.0 (381.6, 406.3) | 8.9 (−9.7, 27.6)NS |
| 14 | 414.6 (400.8, 428.3) | 382.9 (370.2, 395.5) | 31.7 (13.1, 50.3)⁎⁎ |
| 21 | 409.5 (395.2, 423.7) | 394.4 (380.9, 407.9) | 15.1 (−4.5, 34.7)NS |
| 28 | 391.0 (376.5, 405.5) | 379.9 (367.4, 392.4) | 11.1 (−8.0, 30.2)NS |
Data are least squares mean, 90% CI.
NS, not significant.
⁎⁎
P<0.01.