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The effect of wt RON and RON isoforms on downstream signaling of the PI3 K pathway. GSK3β, FOXO3a and its phosphorylated proteins were increased in RON 160 while the remaining isoforms showed minimal variation. PAkt was decreased in wt RON and its isoforms. Please refer to Supplementary Materials Fig. 2a–g for full immunoblotting images.
