. 2016 Sep 13;7(5):e01120-16. doi: 10.1128/mBio.01120-16

TABLE 2 .

Quantitation of sequestration and thrombin staining in cerebral microvessels from pediatric patients with cerebral malaria

Case no.	Diagnosis^a	% PV^b	No. of microvessels with thrombin/sequestration^c				OR	eOR^d	P value^e
Case no.	Diagnosis^a	% PV^b	Neither	Thrombin	IRBC	Both	OR	eOR^d	P value^e
37	CM1	26.2	14	186	1	0		0.04	0.075
100	CM1	37.0	19	103	25	53	0.39	0.40	0.005
99	CM1	60.9	7	36	58	99	0.33	0.37	0.007
95	CM1	84.9	0	9	51	140		0.27	0.066
1	CM1	85.4	26	74	78	22	0.10	0.10	<0.001
96	CM2	35.6	3	26	142	29	0.02	0.03	<0.001
85	CM2	43.1	0	13	132	55		0.03	<0.001
36	CM2	45.0	0	33	67	100		0.04	<0.001
55	CM2	48.1	0	25	65	110		0.06	<0.001
78	CM2	48.1	0	57	46	97		0.04	<0.001
94	CM2	51.3	1	12	54	133	0.21	0.37	0.083
60	CM2	53.3	0	10	44	146		0.30	0.078
26	CM2	56.3	1	27	13	159	0.45	0.81	0.388
83	CM2	63.1	1	44	60	95	0.04	0.07	<0.001
32	CM2	77.2	0	28	29	143		0.17	0.009
69	CM2	80.7	0	1	138	61		0.22	0.310
35	CM2	83.7	0	4	168	28		0.03	0.001
6	CM2	85.7	2	4	145	49	0.17	0.21	0.044
66	CM2	87.7	1	120	20	59	0.02	0.05	<0.001
98	CM2	91.1	1	24	18	157	0.36	0.67	0.279
28	CM2	96.2	0	5	134	61		0.08	0.004
58	CM3	4.3	6	190	2	2	0.03	0.04	0.008
31	CM3	4.5	164	31	4	1	1.32	2.06	0.586
7	CM6	4.8	90	107	3	0		0.21	0.099
10	CM9	12.7	86	110	3	1	0.26	0.39	0.233
Total			422	1,279	1,500	1,800	0.40	0.41	<0.0001

Diagnosis: CM1, sequestration only; CM2, sequestration and fibrin deposition; CM3, coma with no malarial pathology in brain; CM6, severe malarial anemia; CM9, pneumonia and incidental parasitemia.

% PV is the percentage of parasitized cerebral microvessels in autopsy tissue sections used for diagnosis of CM (40).

Two hundred microvessels from each patient were scored for the presence of thrombin, sequestration (IRBC), neither, or both.

Cells with 0 counts made the odds ratio (OR) for those samples impossible to calculate. Estimated OR (eOR) were computed by adding 1 to all cells with a 0 count.

Boldface P values are <0.05.