Table 1.
Study characteristic report.
| Author | Year of publish | Numbers (SCs/Con) |
Age | Type of stroke Acute/chronic |
Gender Male/female |
Type of interventions | Cells dose ×106 |
Route of injection | Follow-up (month) |
Outcome effect indicators | |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Stem cell | Control | ||||||||||
| Bang et al. [9] | 2005 | 5/25 | 63.0 ± 7.5 | Acute | 18/12 | MSC | Routine | 100 | Intravenous | 12 | Barthel |
| Sun et al. [10] | 2008 | 20/22 | 57.8 ± 8.9 | X | 32/10 | MSC | Routine | X | Intravenous | 3 | NIHSS |
| Niu et al. [11] | 2010 | 16/20 | 56 ± 7 | Chronic | 22/14 | NSC | Routine | X | Subarachnoid | 6 | FIM |
| Bhasin et al. [12] | 2011 | 6/6 | 42 | Chronic | 8/4 | MSC | Routine | 50–60 | Intravenous | 6 | FMA, Barthel |
| Deng et al. [13] | 2012 | 15/15 | X | Acute | X | MSC | Routine | 10–50 | Intravenous | 1 | NIHSS |
| He [14] | 2012 | 20/18 | 56.4 ± 7.9 | X | 23/15 | MSC | Routine | 100 | Intravenous | 3 | NIHSS |
| Bhasin et al. [15] | 2012 | 12/12 | 46.5 | Chronic | X | MNC | Routine | 50–60 | Intravenous | 6 | FMA, Barthel |
| Xiao [16] | 2013 | 78/82 | 56.9 ± 9.2 | X | 103/57 | NSC | Routine | 8000 | Subarachnoid | X | FIM |
| Bhasin et al. [17] | 2013 | 14/20 | 45.1 ± 12.1 | Chronic | 32/8 | MNC | Routine | 50–60 | Intravenous | 6 | FMA, Barthel |
| 6/20 | 45.1 ± 12.1 | Chronic | 32/8 | MSC | Routine | 50–60 | Intravenous | 6 | FMA, Barthel | ||
| Liu et al. [18] | 2014 | 29/29 | 55.3 ± 3.6 | Acute | 38/20 | MSC | Routine | 100 | Subarachnoid | 3 | NIHSS, Barthel, FMA |
| Xie et al. [19] | 2014 | 30/30 | 51.4 ± 7.2 | Acute | 37/23 | MSC | Routine | X | Subarachnoid | 6 | NIHSS, Barthel |
| Chen et al. [20] | 2014 | 15/15 | 50.1 ± 7.7 | Chronic | 20/10 | PBSC | Routine | 3–8 | Stereotactic | 12 | NIHSS |
| Prasad et al. [21] | 2014 | 60/60 | 50.7 ± 11.6 | Acute | 77/43 | MSC | Routine | 280.75 | Intravenous | 12 | NIHSS, Barthel |
| Zhang et al. [22] | 2015 | 14/28 | 57.2 ± 7.3 | X | 34/26 | NSC | Routine | 40 | Intravenous | 6 | FIM |
| 18/28 | 56.9 ± 7.5 | X | 34/26 | NSC | Routine | 40 | Subarachnoid | 6 | FIM | ||
| Shen [23] | 2015 | 16/16 | 52 ± 10.4 | Acute | X | UC-MSC | Routine | 1000 | Intra-carotid | 3 | FIM |
| Cai et al. [24] | 2015 | 21/21 | 61.4 ± 6.7 | Chronic | 27/15 | MSC | Routine | 150–600 | Intravenous | 6 | FIM, FMA, Barthel |
MSC: mesenchymal stem cell; NSC: neural stem cell; MNC: bone marrow mononuclear stem cells; PBSC: peripheral blood stem cell; UC-MSC: umbilical cord blood mesenchymal stem cell; X: unknown.