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. 2016 Sep 14;6:33072. doi: 10.1038/srep33072

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Copyright © 2016, The Author(s)

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Relative protein levels (a,b) of Cyp3a and SLCO1B1 in normal rats (CON), rats fed with high-fat diet (HFD), diabetic rats (DM), normal rats treated with phenobarbital (PB); Repaglinide (20 μM) uptake and formation of 1-hydroxymidazolam from midazolam (10 μM) in hepatocytes of CON, HFD, DM and PB rats (c); Atorvastatin (0.5, 2, 10, 40, 100 μM) uptake (d) and formation of ortho-hydroxylation (e) and para-hydroxylation (f) in primary hepatocytes of CON, HFD, DM and PB rats; Uptake and metabolism intrinsic clearance of atorvastatin in primary hepatocytes of CON, HFD, DM and PB rats (g). Correlations between (h) Cyp3a activity (1-hydroxymidazolam formation), (i) SLCO1B1 activity (repaglinide uptake) and cell viability in primary hepatocytes of normal rats (CON), high-fat diet fed rats (HFD), diabetic rats (DM) and phenobarbital pre-treated rats (PB). Full-length blots are presented in the Supplement. Data are represented as mean ± SD (n = 4) *p < 0.05, **p < 0.01 vs. CON. Symbol: AT, atorvastatin, RE: repaglinide, MI: midazolam.