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Plasma concentrations of atorvastatin (AT), ortho-hydroxyatorvastatin (o-AT) and para-hydroxyatorvastatin (p-AT) after single (a–c) or mutiple (d–f) oral dose (10 mg/kg ♦, 20 mg/kg ▲, 40 mg/kg ●) to PB rats and oral dose (40 mg/kg ■) to normal rats, respectively. The AUC (g) and Cmax (h) levels of atorvastatin, ortho-hydroxyatorvastatin and para-hydroxyatorvastatin in normal and PB rats. Data are represented as means ± SD (n = 5). *p < 0.05, **p < 0.01 vs. AH.
