Table 1. Physiological and biochemical characteristics in experiment rats.
| Parameter | CON | HFD | DM | DM-AL | DM-AM |
|---|---|---|---|---|---|
| Body weight (g) | 239.3 ± 12.2 | 305.3 ± 10.2** | 290.2 ± 20.6** | 269.3 ± 5.3** | 250.8 ± 22.4 |
| Liver weight (% of body weight) | 2.85 ± 0.16 | 4.71 ± 0.22** | 5.46 ± 0.27** | 6.94 ± 0.95**## | 10.60 ± 2.25**## |
| Spleen weight (% of body weight) | 0.198 ± 0.027 | 0. 215 ± 0.010 | 0.218 ± 0.024 | 0.264 ± 0.027**# | 0.392 ± 0.033**## |
| FBG (mM) | 7.53 ± 0.34 | 7.76 ± 0.65 | 16.92 ± 1.35** | 18.38 ± 1.75** | 18.34 ± 1.60** |
| FINS (mIU/L) | 29.20 ± 3.06 | 30.12 ± 2.41 | 34.42 ± 3.99 | 32.65 ± 2.15 | 32.51 ± 4.45 |
| HOMA-IR | 9.56 ± 1.05 | 10.32 ± 1.25 | 25.51 ± 1.79** | 27.56 ± 2.01** | 26.92 ± 2.52** |
| TC (mM) | 1.88 ± 0.14 | 2.82 ± 0.72* | 7.98 ± 1.64** | 4.02 ± 0.71**## | 3.42 ± 0.52**## |
| TG (mM) | 1.23 ± 0.14 | 2.56 ± 0.30** | 7.00 ± 1.76** | 5.40 ± 0.50** | 3.75 ± 0.70**## |
Data are represented means ± SD (n = 5) *p < 0.05, **p < 0.01 vs. CON, #p < 0.05, ##p < 0.01 vs. DM rats. Symbols: CON, normal rats; HFD, high-fat diet fed rats; DM, diabetic rats; DM-AL, diabetic rats treated with 10 mg/kg atorvastatin and DM-AM, diabetic rats treated with 20 mg/kg atorvastatin.