Table 2. Replication Results for Circulatory System Conditions Between MSH and CUMC: Phenome-Wide P-values and Pearson Correlation P-values.

Condition	Condition Type	Birth Month Risk - MSH		Birth Month Risk - CUMC		MSH	CUMC	MSH	CUMC	Pearson Corr.
		Low	High	Low	High	Max RR	Max RR	P*	P*	P**
Atrial fibrillation	Symptom	11	2	9	3	1.050	1.056	0.226	2.1 × 10−10	0.007
Coronary arteriosclerosis	Disease	9	1	9	4	1.070	1.039	2.46 × 10−15	3.1 × 10−8	<0.001
Essential hypertension	Symptom	10	1	9	1	1.029	1.020	0.003	1.3 × 10−5	0.005
Congestive cardiac failure	State	11	8	9	1	1.042	1.030	0.760	2.2 × 10−4	0.222
Angina	Symptom	9	1	9	4	1.091	1.070	0.002	6.5 × 10−4	0.003
Cardiomyopathy	Disease	11	8	9	1	1.045	1.064	0.760	8.6 × 10−3	0.030
Chronic myocardial ischemia	Event	11	2	9	4	1.069	1.084	0.834	0.022	0.031
Mitral valve disorder	Disease	9	7	12	3	1.057	1.063	0.562	0.024	0.445
Pre-infarction syndrome	Symptom	9	1	10	6	1.058	1.051	0.022	0.036	0.036

^*Phenome-Wide P-value, FDR adjusted (1688 conditions for CUMC, 1433 for Mt. Sinai).

^**Empirically Derived P-value Using Random Permutations of Mt Sinai’s birth month distribution.

Bold indicates phenome-wide significance was attained at both CUMC and Mt. Sinai.