Figure 4. Bexarotene treatment does not reduce total or phosphorylated tau in ischemic P301L-Tau TG brains.

(A) Representative images of Western blots where total and phosphorylated tau protein were visualized from the peri-ischemic brain area of bexarotene -and vehicle treated ischemic mice. Total protein fractions were separated with gel electrophoresis and probed with antibodies against total human tau protein (HT7 and total Tau) and tau phosphorylated at Thr205 (PT-205). Samples from wildtype animals are shown as controls. (B) The bands were quantified and normalized to β-actin. Analysis with unpaired t-tests between vehicle and bexarotene treated TG animals. N = 4–5/group.