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. 2016 Sep 14;7:161. doi: 10.3389/fgene.2016.00161

FIGURE 2.

FIGURE 2

Lifespans of wild type Caenorhabditis elegans and mutants treated with PQ (0.1 mM) or antioxidants. (A) The PQ treatment has no effect on the lifespan of nuo-6(qm200) mutant (Yang and Hekimi, 2010a). (B) Antioxidant N-acetylcysteine (NAC) fully eliminates the extended longevity of nuo-6(qm200) (Yang and Hekimi, 2010a). (C) sod-12345 worms that lack all five sod genes live a normal lifespan (Van Raamsdonk and Hekimi, 2012). (D) The PQ treatment lengthens the lifespan of the wild type but is without effect on the longevity of sod-3(tm760) knockout mutant (Yee et al., 2014). (E) The lifespan of sod-12345 worms can be increased by the treatment with vitamin C (VitC; Van Raamsdonk and Hekimi, 2012). (F) Treatment with PQ further increases the lifespan of sod-2 mutant to that of the wide-type under the same treatment condition (Yang and Hekimi, 2010a). All figures are redrawn from the published work cited.